After graduating from university, Low began working in local radio in Dundee as a broadcaster and media trainer, before spending five years in The Scottish Office as a ministerial press officer, primarily in the area of industry and economy, but also being involved in events such as Lockerbie and the Piper Alpha oil rig.
She then moved to Standard Life's press office, before becoming head of communications and research at the Scottish Conservative Party. This lead to becoming special adviser to Michael Forsyth, the then secretary of state, in 1995. Following the 1997 election, Low resigned because of "mismanagement by the leadership". She set up Indigo Public Affairs, a communications consultancy specialising in reputation management using media relations, public affairs and crisis communications.
Recently, she has held two terms on the council of CBI Scotland, non-executive member and vice-chairman of NHS 24, as an assistant on the Court of the Merchant Company of Edinburgh and joined the board of trustees at Lloyd TSB's foundation for Scotland in August 2013.