Difference between revisions of "Andrew Wakefield"

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==GMC hearing==
 
==GMC hearing==
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In January 2010, the results of a three-year investigation by the [[General Medical Council]] into the fitness to practice of Wakefield and two other doctors from the MMR research team, Professor [[Simon Murch]] and Professor [[John Walker-Smith]], were announced: they had been found guilty of professional misconduct. Wakefield himself was found guilty of over 30 charges<ref>Brian Deer, [http://www.timesonline.co.uk/tol/news/uk/health/article7009882.ece ‘Callous, unethical and dishonest’: Dr Andrew Wakefield], Sunday Times, 31 Jan 2010, acc 26 May 2010</ref> and was struck off the doctors' list.<ref>Danny Buckland, [http://www.mirror.co.uk/news/top-stories/2010/05/25/dr-damned-115875-22283477/ Rebel medic who sparked a national panic over MMR jab is struck off], The Mirror, 25/5/10, acc 26 May 2010</ref>
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In January 2010, the results of a three-year investigation by the [[General Medical Council]] into the fitness to practise of Wakefield and two other doctors from the MMR research team, Professor [[Simon Murch]] and Professor [[John Walker-Smith]], were announced: they had been found guilty of professional misconduct. Wakefield himself was found guilty of over 30 charges<ref>Brian Deer, [http://www.timesonline.co.uk/tol/news/uk/health/article7009882.ece ‘Callous, unethical and dishonest’: Dr Andrew Wakefield], Sunday Times, 31 Jan 2010, acc 26 May 2010</ref> and was struck off the doctors' list.<ref>Danny Buckland, [http://www.mirror.co.uk/news/top-stories/2010/05/25/dr-damned-115875-22283477/ Rebel medic who sparked a national panic over MMR jab is struck off], The Mirror, 25/5/10, acc 26 May 2010</ref>
  
 
===Conflicts of interest===
 
===Conflicts of interest===

Revision as of 12:29, 27 May 2010

Dr Andrew Wakefield was a researcher who suggested that the measles, mumps and rubella (MMR) combined vaccine might be linked to an increased risk of autism and bowel disorders. In 1998 Wakefield and eleven others published a peer reviewed paper in the Lancet which consisted of a case review of 12 children sequentially referred to London's Royal Free Hospital, where Wakefield was a reader in experimental gastroenterology. The paper said that the children, who all had some inflammatory bowel problems, had in the main developed regressive autism.[1]

Wakefield commented that the children's behaviour changed drastically shortly after they received the MMR jab. He said: "This is a genuinely new syndrome and urgent further research is needed to determine whether MMR may give rise to this complication in a small number of people."[2]

Wakefield theorised that the combination of the three virus strains contained in MMR may overload the body's immune system and cause the bowel disorder to develop.[3]

The publicity following the paper's publication resulted in a dramatic fall in public uptake of the MMR vaccine.[4]

GMC hearing

In January 2010, the results of a three-year investigation by the General Medical Council into the fitness to practise of Wakefield and two other doctors from the MMR research team, Professor Simon Murch and Professor John Walker-Smith, were announced: they had been found guilty of professional misconduct. Wakefield himself was found guilty of over 30 charges[5] and was struck off the doctors' list.[6]

Conflicts of interest

  • Professor Denis McDevitt, who chaired the GMC fitness to practise investigation into Wakefield and colleagues, was himself a member of a 1988 government safety panel which approved Pluserix MMR vaccine as safe for vaccine manufacturer Smith Kline & French Laboratories (later GlaxoSmithKline). This was revealed in previously secret government minutes that were force-disclosed by the MMR litigation brought by parents of alleged MMR-damaged children.[7] Also, at the time that the panel approved the vaccine, McDevitt was being paid as a research fellow by MMR vaccine manufacturer, Smith Kline & French Laboratories.[8][9] The government minutes that reveal these facts are also interesting from the point of view of the adverse reactions reported to the early version of the MMR vaccine, using the subsequently discontinued Urabe strain of mumps virus. The reactions included convulsions, neurological complications, meningitis, and encephalitis. One member of the panel raised concerns about "the potential infectivity of the mumps component of MMR to susceptible contacts", though he was "assured" that it was "not transmissible".[10]
  • Dr Surendra Kumar chaired the GMC fitness to practice hearing into the three Royal Free doctors. He read out the verdict of the General Medical Council (GMC) panel, which condemned the doctors as “dishonest”, “irresponsible”, and as acting “contrary to the clinical interests of this child”.[11] In 2003 Kumar disclosed a shareholding in GlaxoSmithKline.[12] GSK was a defendant in litigation brought by parents of alleged MMR-damaged children under the legal aid scheme, litigation in which the parents employed Wakefield as an expert witness.[13]
  • Dr Andrew Wakefield was accused of a conflict of interest in that he was employed by the group of parents who sued vaccine manufacturers for alleged vaccine damage of their children. Dr Richard Horton, then editor of The Lancet, told the GMC that he had been unaware of this alleged conflict of interest on the part of Wakefield at the time he published Wakefield's MMR paper in The Lancet, though Wakefield told the GMC he had declared it. A discussion of this incident by John Stone, a supporter of the vaccine-damage advocacy group JABS, based on contributions to the BMJ Rapid Responses forum, is here.

Andrew Wakefield was legally correct in stating that there was no conflict of interest in this respect. In defending herself against a parallel allegation of conflict of interest made in Private Eye (19 March 2004), Professor Elizabeth Miller, head of the Health Protection Agency's Immunisation Department and expert witness for the vaccine producers - presumably with the best legal advice - wrote:

there can be no conflict of interest when acting as an expert for the courts, because the duty to the courts overrides any other obligation, including to the person from whom the expert receives the instruction or by whom they are paid.[14]

This legal view was also given by barrister Robert Hantusch in a letter to the Times of 24 February 2004:

But the courts do not consider that the engagement of someone to act as an expert witness in litigation has the effect that that person is then biased. Indeed, if this were the legal position, no paid professional could ever at any time give evidence to a court.[15]
  • Wakefield was also accused of a conflict of interest in that he had filed a patent in 1997 as a co-inventor of an alternative vaccine against MMR, and a pharmaceutical composition for treating inflammatory bowel disease.[16]

See also:

Notes

  1. ↑ Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith. The Lancet, Volume 351, Number 9103 28 February 1998
  2. ↑ MMR research timeline, BBC News Online, 4 Feb 08, acc 26 May 2010
  3. ↑ MMR research timeline, BBC News Online, 4 Feb 08, acc 26 May 2010
  4. ↑ Nick Allen, MMR-autism link doctor Andrew Wakefield defends conduct at GMC hearing, The Telegraph, 27 Mar 08, acc 26 May 2010
  5. ↑ Brian Deer, ‘Callous, unethical and dishonest’: Dr Andrew Wakefield, Sunday Times, 31 Jan 2010, acc 26 May 2010
  6. ↑ Danny Buckland, Rebel medic who sparked a national panic over MMR jab is struck off, The Mirror, 25/5/10, acc 26 May 2010
  7. ↑ Joint Subcommittee on Adverse Reactions to Vaccination and Immunization, Minutes of the meeting held on Tuesday 8 March 1988 at 10.30 am in Room 1612, Market Towers, acc 27 May 2010
  8. ↑ Joint Subcommittee on Adverse Reactions to Vaccination and Immunization, Minutes of the meeting held on Tuesday 8 March 1988 at 10.30 am in Room 1612, Market Towers, acc 27 May 2010
  9. ↑ MMR Conflict of Interest Zone, Private Eye, 8 June - 21 June 2007, acc 27 May 2010
  10. ↑ Joint Subcommittee on Adverse Reactions to Vaccination and Immunization, Minutes of the meeting held on Tuesday 8 March 1988 at 10.30 am in Room 1612, Market Towers, acc 27 May 2010
  11. ↑ Brian Deer, ‘Callous, unethical and dishonest’: Dr Andrew Wakefield, Sunday Times, 31 Jan 2010, acc 26 May 2010
  12. ↑ INDEPENDENT REVIEW PANEL FOR ADVERTISING Declaration of Interests, Medicines Act 1968 Annual Reports 2003, MHRA website, acc 26 May 2010
  13. ↑ Danny Buckland, Rebel medic who sparked a national panic over MMR jab is struck off, The Mirror, 25/5/10, acc 26 May 2010
  14. ↑ Dr Elizabeth Miller, letter to Private Eye (19 March 2004). Cited in Martin V. Hewitt, Parliamentary Protection and Open Science, BMJ Rapid Responses to Annabel Ferriman, MP raises new allegations against Andrew Wakefield, BMJ 2004; 328: 726-a, acc 27 May 2010
  15. ↑ Robert Hantusch, Controversy over accusation of research bias on MMR, Letter to The Times, 24 Feb 04, acc 27 May 2010
  16. ↑ Andrew Jack, MMR row doctor denies abuse of trust, Financial Times, 16 Jul 07, acc 27 May 2010
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