Tom Sanders - Revision history

David at 08:15, 12 July 2014

2014-07-12T08:15:58Z

David at 08:15, 12 July 2014

2014-07-12T08:15:10Z

Claire Robinson: updating link

2014-07-11T18:58:09Z

updating link

Claire Robinson: /* GMWatch response to Sanders' comments */

2012-09-26T16:29:24Z

GMWatch response to Sanders' comments

Claire Robinson: /* Criticism of study on GM maize */

2012-09-26T16:28:41Z

Criticism of study on GM maize

Melissa Jones at 23:38, 23 September 2012

2012-09-23T23:38:14Z

Claire Robinson: /* Criticism of study on GM potatoes */

2012-09-23T18:42:25Z

Criticism of study on GM potatoes

Claire Robinson: /* Criticism of study on GM potatoes */

2012-09-23T18:41:31Z

Criticism of study on GM potatoes

Claire Robinson: /* Affiliations and consultancies */

2012-09-23T18:40:21Z

Affiliations and consultancies

Claire Robinson: /* Affiliations and consultancies */

2012-09-23T18:39:51Z

Affiliations and consultancies

@@ Line 23: / Line 23: @@
 However, this claim only takes into consideration the one factor of calories - not vitamins and minerals, which are arguably a more important factor in choosing a drink. People on a diet still need their nutrients - one could say, more than those eating an unrestricted diet.
-==GM==
+===GM===
-===Criticism of study on GM potatoes - 1998===
+====Criticism of study on GM potatoes - 1998====
 In 1998 researcher Arpad Pusztai of the Rowett Institute in Scotland went public with his team's research showing that GM potatoes had harmful effects on rats (the research was later published in The Lancet<ref>Ewen, S. W. and A. Pusztai (1999). "Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine." Lancet 354(9187): 1353-1354.</ref>).
@@ Line 40: / Line 40: @@
 Sanders (or the publications) did not disclose when he gave his 'spoiler' quotes in 1999 to Scientific American and The Independent that he was either currently or in the recent past (1996) a consultant to Nutrasweet, a Monsanto-owned company. Indeed, The Independent should have known this, as a 1996 article in the same newspaper identified him as a consultant to Nutrasweet (see Affiliations and consultancies).
-===Criticism of study on GM maize - 2012===
+====Criticism of study on GM maize - 2012====
 In September 2012 a study was published showing that the commercialised GM maize NK603 caused massive tumours, organ damage, and premature death in rats fed the maize over a lifetime. Similar effects were seen in rats fed tiny amounts of the herbicide Roundup, which NK603 is engineered to tolerate, below levels permitted in food, feed and drinking water.<ref>Séralini, G. E., E. Clair, et al. (2012). "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize." Food and Chemical Toxicology.</ref>
@@ Line 56: / Line 56: @@
 :The statistical methods are unconventional, there is no clearly defined data analysis plan and probabilities are not adjusted for multiple comparisons.<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>
-===GMWatch response to Sanders' comments on GM maize study===
+=====GMWatch response to Sanders' comments on GM maize study=====
 The following article, incorporating links to sources, is available [http://www.gmwatch.org/index.php?option=com_content&view=article&id=14225 here].

@@ Line 1: / Line 1: @@
 '''Professor Tom Sanders''' is Head of the Nutritional Sciences Research Division, [[King's College London]].<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>
 ==Views==
+===Aspartame/Nutrasweet===
 Sanders has made a name for himself defending the safety of the controversial artificial sweetener aspartame (sold as Nutrasweet) in the media. He said:
@@ Line 17: / Line 23: @@
 However, this claim only takes into consideration the one factor of calories - not vitamins and minerals, which are arguably a more important factor in choosing a drink. People on a diet still need their nutrients - one could say, more than those eating an unrestricted diet.
-==Affiliations and consultancies==
+==GM==
+===Criticism of study on GM potatoes - 1998===
 In 1998 researcher Arpad Pusztai of the Rowett Institute in Scotland went public with his team's research showing that GM potatoes had harmful effects on rats (the research was later published in The Lancet<ref>Ewen, S. W. and A. Pusztai (1999). "Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine." Lancet 354(9187): 1353-1354.</ref>).
@@ Line 40: / Line 40: @@
 Sanders (or the publications) did not disclose when he gave his 'spoiler' quotes in 1999 to Scientific American and The Independent that he was either currently or in the recent past (1996) a consultant to Nutrasweet, a Monsanto-owned company. Indeed, The Independent should have known this, as a 1996 article in the same newspaper identified him as a consultant to Nutrasweet (see Affiliations and consultancies).
-==Criticism of study on GM maize==
+===Criticism of study on GM maize - 2012===
 In September 2012 a study was published showing that the commercialised GM maize NK603 caused massive tumours, organ damage, and premature death in rats fed the maize over a lifetime. Similar effects were seen in rats fed tiny amounts of the herbicide Roundup, which NK603 is engineered to tolerate, below levels permitted in food, feed and drinking water.<ref>Séralini, G. E., E. Clair, et al. (2012). "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize." Food and Chemical Toxicology.</ref>
@@ Line 118: / Line 118: @@
 If we were Sanders, we wouldn't go there.
+==Career==
 ==Contact==
 :Address:
-:...
+:Head of Diabetes & Nutritional Sciences Division
-:...
+:Professor of Nutrition & Dietetics
-:...
+:School of Medicine
-:...
+:King's College London
+:4.72 Franklin-Wilkins Building
+:150 Stamford Street
-:Phone:
+:London SE1 9NH
-: ...
+:Tel: +44 (0)20 7848 4273
-:Email:
+:Email:  tom.sanders@kcl.ac.uk
-:...
+:Web: [http://www.kcl.ac.uk/medicine/research/divisions/dns/about/people/profiles/tomsanders.aspx Tom Sanders], King's college bio page.
 ==Resources==

@@ Line 19: / Line 19: @@
 ==Affiliations and consultancies==
-An article in The Independent in 1996 described Sanders as "Nutrasweet's professional consultant".<ref>Rita Carter, [http://www.independent.co.uk/life-style/health-and-families/health-news/the-truth-about-sugar-substitutes-1353100.html The truth about sugar substitutes], The Independent, 19 Nov 1996</ref> At this time, Nutrasweet was owned by [[Monsanto]], which acquired G. D. Searle & Company, the company that owned the patent on aspartame, in 1985. <ref>Nutrasweet Company, [http://www.nutrasweet.com/company.asp Company profile], 2003, acc 22 Sept 2012</ref> Investment firm J.W. Childs Associates purchased Nutrasweet from Monsanto in 2000.<ref>D L Dewey, [http://www.dldewey.com/columns/ricof.htm $350 Million Plus Lawsuit Filed Against Nutrasweet - Monsanto Aspartame Sweetener], Sept 15 2004, acc Sept 22 2012</ref> Aspartame is commonly manufactured using genetically modified bacteria.<ref>GMO Compass, [http://www.gmo-compass.org/eng/database/e-numbers/102.aspartame.html Aspartame], Aug 13, 2008, acc Sep 22 2012</ref>
+An article in The Independent in 1996 described Sanders as "Nutrasweet's professional consultant".<ref>Rita Carter, [http://archive.today/ctqKH The truth about sugar substitutes], The Independent, 19 Nov 1996</ref> At this time, Nutrasweet was owned by [[Monsanto]], which acquired G. D. Searle & Company, the company that owned the patent on aspartame, in 1985. <ref>Nutrasweet Company, [http://www.nutrasweet.com/company.asp Company profile], 2003, acc 22 Sept 2012</ref> Investment firm J.W. Childs Associates purchased Nutrasweet from Monsanto in 2000.<ref>D L Dewey, [http://www.dldewey.com/columns/ricof.htm $350 Million Plus Lawsuit Filed Against Nutrasweet - Monsanto Aspartame Sweetener], Sept 15 2004, acc Sept 22 2012</ref> Aspartame is commonly manufactured using genetically modified bacteria.<ref>GMO Compass, [http://www.gmo-compass.org/eng/database/e-numbers/102.aspartame.html Aspartame], Aug 13, 2008, acc Sep 22 2012</ref>
 Food writer Felicity Lawrence, in a 2010 article that scathingly commented on the nutritional value of manufactured breakfast cereals, reported that the cereals manufacturing industry had

@@ Line 56: / Line 56: @@
 :The statistical methods are unconventional, there is no clearly defined data analysis plan and probabilities are not adjusted for multiple comparisons.<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>
-===GMWatch response to Sanders' comments===
+===GMWatch response to Sanders' comments on GM maize study===
-This article, incorporating links to sources, is available [http://www.gmwatch.org/index.php?option=com_content&view=article&id=14225 here].
+The following article, incorporating links to sources, is available [http://www.gmwatch.org/index.php?option=com_content&view=article&id=14225 here].
 Sanders's comment that "Most toxicology studies are terminated at normal lifespan i.e. 2 years. Immortality is not an alternative" is baffling, as Seralini too terminated his experiment at 2 years.

← Older revision		Revision as of 16:28, 26 September 2012
Line 55:		Line 55:

	:The statistical methods are unconventional, there is no clearly defined data analysis plan and probabilities are not adjusted for multiple comparisons.<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>		:The statistical methods are unconventional, there is no clearly defined data analysis plan and probabilities are not adjusted for multiple comparisons.<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>
		+
		+	===GMWatch response to Sanders' comments===
		+
		+	This article, incorporating links to sources, is available [http://www.gmwatch.org/index.php?option=com_content&view=article&id=14225 here].
		+
		+	Sanders's comment that "Most toxicology studies are terminated at normal lifespan i.e. 2 years. Immortality is not an alternative" is baffling, as Seralini too terminated his experiment at 2 years.
		+
		+	Sanders is incorrect to say that 2 years for a rat is normal lifespan. It corresponds to around 65 years in human terms.
		+
		+	Sanders's comment that "No food intake data is provided or growth data" is disingenuous. You cannot squash all your data into a peer-reviewed paper. Editors give you a word count.
		+
		+	The normal response to the absence of a certain piece of information in a paper - a piece of information that is not of central relevance to the study - would be to ask Seralini's team for the information and consider the response, not to throw a hissy fit and throw out the entire paper.
		+
		+	But "experts" recruited to dismiss the inconvenient findings of independent scientists do not behave normally.
		+
		+	Here is that information, which apparently someone did ask for, and got. In Seralini's experiment, the rats had unrestricted access to food and water and there were no differences in consumption or drinking levels between controls and test groups except for the group exposed to the highest Roundup concentration in drinking water. This group of rats drank less water (wouldn't you?).
		+
		+	Sanders's claim that the Sprague-Dawley (SD) strain of rat that Seralini used "is very prone to mammary tumours" backfires on him badly. The SD rat is widely used in toxicological experiments, including in the long-term toxicity and carcinogenicity tests performed by Monsanto on glyphosate to gain the 2002 approval for marketing in the EU. The SD rat was also used in Monsanto's 90-day feeding trial on this same maize, NK603, that led to its approval in the EU.
		+
		+	So if Seralini used "the wrong rat", so does industry, and we should throw out the hundreds of industry studies on chemicals and GMOs that have used the SD rat. That means goodbye glyphosate, thousands of chemicals, and many GM foods.
		+
		+	And data from the Ramazzini Institute in Italy shows that far from being unusually "prone" to tumours, the SD rat is an excellent model for human carcinogenicity and is about as prone to tumours, both "spontaneous" and environmentally induced, as we are.
		+
		+	Which explains why so many independent scientists, as well as industry toxicological studies, continue to use the SD rat.
		+
		+	We wonder if Sanders has noticed that 1 in 3 people in the UK get cancer - about the same as Seralini's control rats. And rates of breast cancer - which may or may not be a human equivalent to the mammary tumours seen in the rats - are escalating. It's been the most common type of cancer in the UK since 1997.
		+
		+	The key point about Seralini's tumour findings was that the controls got some tumours, but that the treated groups got significantly more tumours, which began sooner and were more aggressive, than the control groups.
		+
		+	So even if a researcher used a strain of rat that was bizarrely prone to tumours (though this is not the case with Seralini), this would not matter in the context of the controlled experiment, because you are looking at the additional number of tumours caused by the treatment, over and above the "spontaneous" background level.
		+
		+	To illustrate the point by an analogy: We know that a small proportion of people who never smoke get lung cancer. If you smoke, the rate/risk of getting lung cancer is about 12 times higher than if you don't smoke. The measurement is called a "relative risk". So, imagine that there is an ethnic group of people with a higher rate of naturally occurring lung cancer. We know that if people in that group smoke, their rate of lung cancer will still increase like everybody else.
		+
		+	This is a basic principle of science and it is worrying that Sanders's claims on this front are not challenged by the science correspondents of the media.
		+
		+	Sanders also implies that the lack of restriction on the rats' diets was a confusing factor because it made the rats more prone to tumours. But again, the control rats also had an unrestricted diet but got far fewer tumours.
		+
		+	And how many humans does Sanders know who eat a "restricted" diet in order to avoid getting cancer from their intake of GM foods and Roundup? Unrestricted feeding is a standard practice in such research, and reflects human reality.
		+
		+	Now we move on to Sanders's comment, "There is a lack of information on the composition of the diet."
		+
		+	We wonder if Sanders has even read the paper that he is dismissing.
		+
		+	Seralini clearly says that the rats' diet was the standard diet known as A04 (Safe, France). You can get details of this diet with a 30-second Google. The only difference in the diets was the two treatment substances: GM maize NK603 and Roundup.
		+
		+	This is proper scientific practice. The only variables should be the substances you are testing; in this case, the GM maize and Roundup. It is also in accord with EU law, which says that the GM maize must be compared with its non-GM counterpart that is as genetically similar as possible, but that hasn't been genetically engineered. This spots differences caused by the genetic engineering process, which is the point of the GMO safety assessment.
		+
		+	Seralini provides much more dietary information than many authors of such studies and massively more than Monsanto gave in its 90-day feeding trial with NK603 maize, which led to its approval. Seralini's team published a re-analysis of Monsanto's data, which wasn't peer-reviewed and published, in a 2009 paper (de Vendomois, J. S., F. Roullier, et al. (2009). A comparison of the effects of three GM corn varieties on mammalian health. Int J Biol Sci 5(7): 706–726.).
		+
		+	Read this paper and prepare to be shocked. Monsanto:
		+	*used a number of different control diets containing unrelated varieties of maize, introducing many variables into the experiment that hide the effects of the GM process
		+	*used far more control animals than treated, which again would hide effects of the GM diet, and
		+	*provided no data to show that the non-GM control diets were even non-GM!
		+
		+	Sanders then makes a speculative claim that the effects found by Seralini's team could have been due to mycotoxins from improper storage.
		+
		+	But all feeds were biochemically analysed to make sure they weren't contaminated with such toxins.
		+
		+	Let's assume, for the sake of argument, that some mystery toxin was present that escaped the researchers' notice. (Note: if we put this forward as a reason to dismiss Seralini's study, we have to prove it through further experiments. Until then, our argument is simply a hypothesis.)
		+
		+	We know from Seralini's paper that the GM and non-GM maize varieties were grown side-by-side in the same conditions. If storage conditions were also the same, as would be expected in an experiment of this type, then that leaves us with another interesting question: why would the GM maize end up with a mystery toxin in it, which the non-GM maize didn't have in such dangerous quantities?
		+
		+	If we were Sanders, we wouldn't go there.

	==Contact==		==Contact==

← Older revision		Revision as of 23:38, 23 September 2012
Line 1:		Line 1:
−	~~Prof [[~~Tom Sanders]] is Head of the Nutritional Sciences Research Division, King's College London.<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>	+	'''Professor Tom Sanders''' is Head of the Nutritional Sciences Research Division, [[King's College London]].<ref>Science Media Centre, [http://www.sciencemediacentre.org/pages/press_releases/12-09-19_gm_maize_rats_tumours.htm Expert reaction to GM maize causing tumours in rats], 19 Sept 2012, acc 22 Sept 2012</ref>

	==Views==		==Views==

@@ Line 38: / Line 38: @@
 Sanders also claimed in his interview with The Independent that the ill effects seen in the rats were due to protein deprivation, when in fact the treatment and control diets had the same amount of protein (were isoproteinic) and all diets met government standards for experimental rodent diets.
-Sanders seemingly did not disclose (or the publications did not report) when he gave his 'spoiler' quotes in 1999 to Scientific American and The Independent that he was either currently or in the recent past (1996) a consultant to Nutrasweet, a Monsanto-owned company. Indeed, The Independent should have known this, as a 1996 article in the same newspaper identified him as a consultant to Nutrasweet (see Affiliations and consultancies).
+Sanders (or the publications) did not disclose when he gave his 'spoiler' quotes in 1999 to Scientific American and The Independent that he was either currently or in the recent past (1996) a consultant to Nutrasweet, a Monsanto-owned company. Indeed, The Independent should have known this, as a 1996 article in the same newspaper identified him as a consultant to Nutrasweet (see Affiliations and consultancies).
 ==Criticism of study on GM maize==